1.基本信息
段东柱，男，汉族，1984年10月生，甘肃通渭人，博士，副教授，硕士研究生导师。2008年毕业于陇东学院生物科学专业，获理学学士学位；2011年毕业于兰州理工大学微生物与生化药学专业，获理学硕士学位；2014年毕业于兰州大学有机化学专业，获理学博士学位；2014年8月至2015年7月，任职于贵州医科大学基础医学院；2018年至2019年，作为访问学者在中国科学院昆明动物所进行肿瘤生物学研究；已在包括J. Biol. Chem., Free Radic. Biol. Med., Bioorg. Chem., J. Am. Chem. Soc., Med. Res. Rev., Cancer Lett., J. Med. Chem.等化学与生物医学国际主流SCI期刊发表学术论文40余篇，被引用1800余次，H指数为22；现主持国家自然科学基金面上项目1项，先后参与国家自然科学基金项目6项；2015年7月进入太阳成集团tyc151工作至今。
2.研究方向
1)药物化员工物学。
2)生化药理学。
3.开设课程
承担了《天然药物化学》、《有机化学实验》、《物理化学实验》、《科技论文写作与文献检索》和《化学专业英语》等课程的教学。
4.主持科研项目
1)国家自然科学基金面上项目，五味子三萜逆转HECTD3泛素化修饰p62诱导自噬促进三阴性乳腺癌细胞耐药的研究，57万，2021年1月-2024年12月，编号82073316。
2)陕西省科技厅项目，以TrxR和Hsp90为双靶点的抗肿瘤成分发现及作用机理，3万，2018年1月-2019年12月，编号2018JQ2051。
3)陕西省教育厅重点项目，基于两种秦岭特色药用植物的硫氧还蛋白还原酶抑制剂的发现
及抗肿瘤机制研究，5万，2016年1月-2017年12月，编号16JS009。
5. 发表论文
1)DongzhuDuan*, Yanru Wang, Dabo Pan, XiaojieJin, Yunyun Yan, Peng Song, Le Wang, Jian Xiao, Zihua Wang*, Xiaoling Wang*.Rheumatoid arthritis drug sinomenine induces apoptosis of cervical tumor cells by targeting thioredoxin reductase in vitro and in vivo.Bioorganic Chemistry, 2022, 122:105711.(SCI,IF=5.307)
2) DongzhuDuan*, Xiaolu Feng,Dabo Pan, Le Wang, Yanru Wang, Xiaoling Wang*.Oridonin induces oxidative stress-mediated cancer cells apoptosis via targeting thioredoxin reductase.Current Pharmaceutical Biotechnology,2022, 23:1647-1657.(SCI, IF=2.829)
3)DongzhuDuan*, Yanru Wang, XiaojieJin, Mi Li, Le Wang, Yunyun Yan, Jian Xiao, Peng Song*, Xiaoling Wang*. Natural diterpenoideriocalyxin B covalently modifies glutathione and selectively inhibits thioredoxin reductase inducing potent oxidative stress-mediated apoptosis in colorectal carcinoma RKO cells. Free Radical Biology and Medicine, 2021, 177:15-23. (SCI, IF=8.101)
4) DongzhuDuan*, Yanru Wang, Dabo Pan, Le Wang, Jian Xiao, Peng Song*, XiaojieJin, Xiaoling Wang*.Targeting thioredoxin reductase by deoxyelephantopin from Elephantopusscaber triggers cancer cell apoptosis.Archives of Biochemistry and Biophysics, 2021, 711:109028. (SCI, IF=4.114)
5) Junmin Zhang1, Dongzhu Duan1, Alsiddig Osama, Jianguo Fang*.Natural molecules targeting thioredoxin system and their therapeutic potentials.Antioxidants & Redox Signaling, 2021, 34:1083-1107.(1Co-first author, SCI, IF=8.401)
6)Maobo Huang1, Yuanfei Zhou1, Dongzhu Duan1, Chuanyu Yang, Zhongmei Zhou, Fubing Li, Yanjie Kong, Yi-Ching Hsieh, Ruihan Zhang, Wenping Ding, Weilie Xiao, PemaTenzin Puno*, Ceshi Chen*. Targeting ubiquitin conjugating enzyme UbcH5b by a triterpenoid PC3-15 from Schisandra plants sensitizes triple-negative breast cancer cells to lapatinib.Cancer Letters, 2021, 504:125-136. (1Co-first author, SCI, IF=9.756)
7) Junmin Zhang, DongzhuDuan, Zi-Long Song, Tianyu Liu, YananHou, Jianguo Fang*.Small molecules regulating reactive oxygen species homeostasis for cancer therapy.Medicinal Research Reviews,2021, 41: 342-394. (SCI, IF=12.944)
8)Junmin Zhang, DongzhuDuan,Jianqiang Xu, Jianguo Fang*. A redox-dependentcopper carrier promotes cellular copper uptake and oxidative stress-mediatedapoptosis of cancer cells. ACS Applied Materials & Interfaces, 2018, 39:33010-33021. (SCI, IF=10.383)
9)DongzhuDuan, Junmin Zhang, Juan Yao, Yaping Liu, Jianguo Fang* Targeting thioredoxin reductase by parthenolide Contributes to inducing apoptosis of HeLa cells. Journal of Biological Chemistry, 2016, 291:10021-10031. (SCI, IF=5.157)
10)DongzhuDuan, Baoxing Zhang, Juan Yao, Yaping Liu, Jinyu Sun, Chunpo Ge, Shoujiao Peng, Jianguo Fang*. Gambogic acid inducing apoptosis in hepatocellular carcinoma SMMC-7721 cells by targeting cytosolic thioredoxin reductase. Free Radical Biology and Medicine, 2014, 69:15-25. (SCI, IF=8.101)
11)DongzhuDuan, Baoxing Zhang, Juan Yao, Yaping Liu, Jianguo Fang*.Shikonin targeting the cytosolic thioredoxin reductase to induce ROS-mediated apoptosis in human promyelocytic leukemia HL-60 cells.Free Radical Biology and Medicine,2014, 70:182-193. (SCI, IF=8.101)
12)Liangwei Zhang, Dongzhuduan, Yaping Liu, Chunpo Ge, Jinyu Sun, Xuemei Cui, Jianguo Fang*. Highly selective off-on fluorescent probe for imaging thioredoxin reductase in Living Cells.Journal of the American Chemical Society, 2014, 136: 226-233. (SCI, IF=16.383)
6. 联系方式
通讯地址：陕西省宝鸡市高新大道1号太阳成集团tyc151
邮编：721013邮箱: duandongzhu@126.com
